Hair miR-29a Levels Are Decreased in Patients with Scleroderma

    October 2013 in “ Experimental dermatology ”
    Risa Takemoto, Masatoshi Jinnin, Zhongzhi Wang, Hideo Kudo, Kuniko Inoue, Wakana Nakayama, Asako Ichihara, Toshikatsu Igata, Ikko Kajihara, Satoshi Fukushima, Hironobu Ihn
    TLDR Scleroderma patients have lower hair miR-29a levels.
    The study found that hair miR-29a levels were significantly lower in scleroderma patients compared to control subjects and dermatomyositis patients. This suggests that hair miR-29a could serve as an independent biomarker for scleroderma, as there was no strong correlation between miR-29a levels in hair, skin, and serum. Additionally, scleroderma patients with decreased miR-29a levels had a higher prevalence of phalangeal contracture. The study concluded that hair-derived miRNAs might be more useful for diagnosing chronic or genetic diseases like scleroderma rather than acute diseases. However, larger-scale studies are needed to confirm these findings.
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