Hair Shaft miRNA-221 Levels as a New Tumor Marker of Malignant Melanoma

    December 2014 in “ Journal of dermatology
    Taisuke Inada, Satoshi Fukushima, Minoru Murai, Masatoshi Jinnin, Azusa Miyashita, Shiro Nakahara, Junji Yamashita, Jun Aoi, Shinichi Masuguchi, Hironobu Ihn
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    TLDR Hair shaft miR-221 levels can help detect malignant melanoma.
    The study investigated the potential of hair shaft miR-221 levels as a marker for malignant melanoma (MM). It found that miR-221 levels in the hair shaft were significantly higher in MM patients compared to controls. The detection rates of elevated hair shaft miR-221 were similar to those of serum 5-S-CD, a commonly used MM marker. This suggested that measuring hair shaft miR-221 could be a valuable, non-invasive method for MM detection, providing new insights into the relationship between miR-221 and MM. This was the first report to explore hair shaft miR-221 levels in MM patients.
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