TLDR Developing microRNA-based treatments is hard but has potential.
MicroRNAs (miRs), short non-coding RNAs that regulate gene expression, are involved in various diseases like stroke, cancer, and androgenic alopecia. Specific miRs such as miR-511, miR-27-3p, and miR-214 have potential as biomarkers. Despite challenges like ubiquitous expression, non-specificity, and delivery issues in developing miR therapeutics, the article suggests that identifying significant miRs in diseases, developing miR-inhibitors with higher specificity, and using plant-derived miRs are promising opportunities. As of the article's publication, only 20 miR-therapeutics have entered clinical trials, with none reaching phase III trials.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
12 citations,
July 2020 in “Aging” The protein EZH2 blocks microRNA-22, increasing STK40 protein, which helps hair follicle stem cells change and grow hair.
12 citations,
November 2020 in “Journal of Dermatological Science” Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.
12 citations,
October 2021 in “Cells” Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.
2 citations,
October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
