Life Sciences Discovery and Technology Highlights

November 2019 in “ SLAS technology ”

David Yeo, Tal Murthy

Sox11 Sox4 microRNA miR-10a miR-10b miR-21 miR-155 FGF7 hyperspectral imaging thermoresponsive hydrogels nanofiber-expanded CD34+ cells

TLDR New findings suggest certain genes and microRNAs are crucial for wound healing, and innovative technologies like smart bandages and apps show promise in improving treatment.

The document from December 2019 highlighted several key discoveries in life sciences and technology, particularly in wound healing. Sox11 and Sox4 were found to enhance murine wound repair by reactivating an embryonic gene program. Differential microRNA profiles, such as miR-10a/b and miR-21, were linked to varying healing responses, with miR-21 promoting faster wound closure. In diabetic wound healing, inhibiting miR-155 improved outcomes by restoring FGF7 expression and reducing inflammation. Hyperspectral imaging was proposed for noninvasive monitoring of articular cartilage. Innovations included a wearable luminescent gas-sensing design for oxygen measurement, the WoundCheck app for postoperative monitoring, and omniphobic paper-based smart bandages for real-time biomarker detection. Thermoresponsive hydrogels and nanofiber-expanded CD34+ cells showed promise in promoting wound healing and reducing inflammation in diabetic mice. These advancements aimed to enhance patient care and reduce healthcare costs.

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