Life Sciences Discovery and Technology Highlights

November 2019 in “ SLAS technology ”

David Yeo, Tal Murthy

Sox11 Sox4 microRNA miR-10a miR-10b miR-21 miR-155 FGF7 hyperspectral imaging thermoresponsive hydrogels nanofiber-expanded CD34+ cells

TLDR New findings suggest certain genes and microRNAs are crucial for wound healing, and innovative technologies like smart bandages and apps show promise in improving treatment.

The document from December 2019 highlighted several key discoveries in life sciences and technology, particularly in wound healing. Sox11 and Sox4 were found to enhance murine wound repair by reactivating an embryonic gene program. Differential microRNA profiles, such as miR-10a/b and miR-21, were linked to varying healing responses, with miR-21 promoting faster wound closure. In diabetic wound healing, inhibiting miR-155 improved outcomes by restoring FGF7 expression and reducing inflammation. Hyperspectral imaging was proposed for noninvasive monitoring of articular cartilage. Innovations included a wearable luminescent gas-sensing design for oxygen measurement, the WoundCheck app for postoperative monitoring, and omniphobic paper-based smart bandages for real-time biomarker detection. Thermoresponsive hydrogels and nanofiber-expanded CD34+ cells showed promise in promoting wound healing and reducing inflammation in diabetic mice. These advancements aimed to enhance patient care and reduce healthcare costs.

View this study on journals.sagepub.com →

Discuss this study in the Community →

Similar Research

5 / 277 results

Analysis of Changes in MicroRNA Expression Profiles in Response to the Troxerutin-Mediated Antioxidant Effect in Human Dermal Papilla Cells

research Analysis of Changes in MicroRNA Expression Profiles in Response to the Troxerutin-Mediated Antioxidant Effect in Human Dermal Papilla Cells

12 citations, May 2015 in “Molecular Medicine Reports”

Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.

research Implication of MicroRNA Regulation in Para-Phenylenediamine-Induced Cell Death and Senescence in Normal Human Hair Dermal Papilla Cells

8 citations, March 2015 in “Molecular Medicine Reports”

Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

25 citations, September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

research TGF-β Family Signaling in Stem Cells

132 citations, August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

research Androgen Receptor: A Promising Therapeutic Target in Breast Cancer

21 citations, March 2019 in “Critical Reviews in Clinical Laboratory Sciences”

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.