Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

February 2023 in “ International Journal of Molecular Sciences ”

Kaja Troha, Domen Vozel, Matevž Arko, Apolonija Bedina Zavec, Drago Dolinar, Matej Hočevar, Zala Jan, Matic Kisovec, Boštjan Kocjančič, Ljubiša Pađen, Manca Pajnič, Samo Penič, Anna Romolo, Neža Repar, Vesna Spasovski, Nejc Steiner, Vid Šuštar, Aleš Iglič, Damjana Drobne, Ksenija Kogej, Saba Battelino, Veronika Kralj-Iglič

platelet-rich plasma extracellular vesicles PVRP growth factors alopecia hair density hair count hair shedding hair diameter PRP

TLDR Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP) has potential in enhancing tissue regeneration and improving hair conditions, but its effectiveness varies due to individual differences.

The review discusses the therapeutic potential of Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP), a complex substance used in various medical fields. PVRP contains bioactive molecules like growth factors, amino acids, hormones, and more, which are involved in healing mechanisms. Extracellular vesicles (EVs), small particles shed from activated platelets, play a crucial role in cellular signaling and mediate communication between cells. The effectiveness of PVRP treatment varies due to differences in patients' plasma composition, influenced by factors such as age, sex, diet, and physical activity. PVRP has shown potential in enhancing tissue regeneration in various medical fields, including maxillofacial surgery, dermatology, ophthalmology, and more. In the treatment of alopecia, PVRP has been found to significantly improve hair density, hair count, hair shedding, and hair diameter in patients with mild conditions. However, more randomized comparative studies are needed to confirm these findings. The review emphasizes the need for individual consideration of PVRP products in clinical use due to the complexity of interactions influencing PVRP composition.

View this study on mdpi.com →

Discuss this study in the Community →

Cited in this study

10 / 10 results

research Determination of 19 Steroid Hormones in Human Serum and Urine Using Liquid Chromatography-Tandem Mass Spectrometry

7 citations , November 2022 in “Toxics”

The method accurately measures 19 steroid hormones in human blood and urine using a small sample and is suitable for large-scale monitoring.

research The Efficacy of Platelet-Rich Plasma in Hair Restoration and Facial Aesthetics: A Systematic Review and Meta-Analysis

31 citations , January 2019 in “Journal of Cutaneous Medicine and Surgery”

Platelet-Rich Plasma (PRP) therapy can promote hair growth and improve facial aesthetics, including reducing acne scars and facial burns, and it works best with three initial monthly injections.

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis

54 citations , December 2018 in “Journal of The European Academy of Dermatology and Venereology”

Low level laser therapy works best for hair loss, followed by PRP, finasteride, and minoxidil.

research Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin

51 citations , December 2018 in “JAMA Dermatology”

PRP injections may improve skin texture and wrinkles based on patient feedback, despite no significant changes seen by dermatologists.

research Platelet-Rich Plasma for the Treatment of Androgenic Alopecia: A Systematic Review

23 citations , June 2018 in “Facial Plastic Surgery”

Platelet-Rich Plasma (PRP) is a low-risk treatment for Androgenic Alopecia (AGA) that generally improves hair count or density, but more research is needed for optimization.

research Injections of Platelet-Rich Plasma for Androgenic Alopecia: A Systematic Review

25 citations , July 2017 in “Journal of Stomatology, Oral and Maxillofacial Surgery”

PRP injections help regrow hair, reduce hair loss, and increase hair thickness, but effects decrease without ongoing treatment.

research Role of Leukocyte-Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction

13 citations , June 2016 in “Journal of neurological surgery”

Using L-PRF membranes for skull base surgery might help healing, but more research is needed.

research Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

Using platelet-rich plasma with microneedling works better for acne scars than microneedling with water.

research Systematic Review of the Use of Platelet-Rich Plasma in Aesthetic Dermatology

113 citations , July 2015 in “Journal of Cosmetic Dermatology”

Platelet-rich plasma may help with hair growth and skin quality but more research is needed to confirm its effectiveness.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , November 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.