Advances in Platelet Rich Plasma-Derived Extracellular Vesicles for Regenerative Medicine: A Systematic-Narrative Review

The systematic-narrative review analyzed 20 studies on the use of Platelet Rich Plasma-Derived Extracellular Vesicles (PRP-EVs) in regenerative medicine. PRP-EVs have shown potential in various fields including osteoarthritis, tissue regeneration, diabetic retinopathy, intervertebral disc degeneration, muscle injury, wound healing, hair loss, osteonecrosis, and dental pulp or cartilage regeneration. They have been found to promote cell proliferation, migration, and various healing processes. In the field of hair growth, PRP-EVs have shown potential in enhancing the inductivity of hair dermal papilla cells. However, the lack of standardization in PRP and EV procedures makes it challenging to compare results across studies. The review calls for establishing standardized conditions to ensure optimized and detailed protocols and define parameters such as the dose or the EV origin. Further studies are also needed to understand the real contribution of EVs to PRP in terms of composition and functionality.