Role of Leukocyte-Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction

    June 2016 in “ Journal of neurological surgery ”
    Liuba Soldatova, Raewyn Campbell, A El-Khatib, Thomas Schmidt, Nelson Pinto, Jaime Pinto, Daniel M. Prevedello, Leo F. Ditzel Filho, Bradley A. Otto, Ricardo L. Carrau
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    Studysummary This study suggests that leukocyte-platelet-rich fibrin membranes may aid postoperative healing in endoscopic skull base surgery, with some patients showing reduced crusting and low rates of cerebrospinal fluid leaks. Our plain-language summary of this paper — not a Tressless recommendation.
    In a pilot study from January to May 2015 involving 47 patients, researchers evaluated the use of leukocyte-platelet-rich fibrin (L-PRF) in healing after endoscopic endonasal skull base surgery. The patients had resections of sellar, parasellar, and suprasellar lesions and received L-PRF membranes for skull base reconstruction. At 21 days post-surgery, 17 patients (42%) showed improved crusting scores from their 7-day postoperative examination, with 10 patients (23%) having no crusting. However, 14 patients (34%) had no change, and 4 patients (8.5%) experienced postoperative cerebrospinal fluid leaks requiring surgical repair. The study suggested that L-PRF membranes might be useful for skull base defect reconstruction, but emphasized the need for larger studies with control groups to better understand its effectiveness.
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