Overview and Future of Hemocomponents and Natural Guided Regeneration

The 2017 document reviews the development and use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in regenerative medicine, especially in surgical applications. It details the evolution of these hemocomponents since the 1970s, their classification, and the distinction between PRP and PRF, including leukocyte-enriched versions (L-PRP and L-PRF). The review highlights the suitability of L-PRF clots and membranes for oral and maxillofacial surgery due to their ability to release growth factors and promote leukocyte migration over time. However, it points out the absence of international standards for characterizing implantable material surfaces and calls for more standardized clinical studies to understand the full potential and optimal effects of L-PRF in regenerative procedures, given the mixed clinical outcomes reported in the literature.