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GlossaryKeratin 10 (K10)

protein crucial for skin's structural integrity and resilience

Keratin 10 (KRT10) is a type of protein found in the upper layers of the skin, specifically in the epidermis. It plays a crucial role in maintaining the structural integrity and resilience of the skin by forming a network of intermediate filaments that provide mechanical support. Mutations in the KRT10 gene can lead to skin disorders such as epidermolytic hyperkeratosis, which is characterized by blistering and thickening of the skin.

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research Missense Mutation Y449H of the K10 Gene in a Patient with Severe Epidermolytic Ichthyosis

3 citations , March 2019 in “European Journal of Dermatology”

A specific gene mutation (Y449H in K10) was found in a patient with severe skin disorder.

research Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

32 citations , April 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Loss of keratin K2 causes skin problems and inflammation.

research Clinicopathological Features and Expression of Four Keratins (K10, K14, K17, and K19) in Six Cases of Eruptive Vellus Hair Cysts

8 citations , April 2014 in “Clinical and Experimental Dermatology”

Eruptive vellus hair cysts likely originate from the infrainfundibulum and sebaceous duct.

research Severe Abnormalities in the Oral Mucosa Induced by Suprabasal Expression of Epidermal Keratin K10 in Transgenic Mice

15 citations , September 2002 in “Journal of Biological Chemistry”

Abnormal keratin expression in mice causes severe oral issues, affecting feeding.

research Expression of Keratins K6 and K16 in Regenerating Mouse Epidermis Is Less Restricted by Cell Replication Than the Expression of K1 and K10

13 citations , July 1994 in “PubMed”

Keratins K6 and K16 are expressed more freely in regenerating mouse skin than K1 and K10.

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