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This study found that TPA treatment induced expression of keratins K6 and K16 in mouse epidermis, with K6 expressed across all cell layers and K16 only in post-mitotic cells.

A specific gene mutation (Y449H in K10) was found in a patient with severe skin disorder.

In this study, minoxidil sulfate was found to relax norepinephrine-induced contractions in rabbit mesenteric arteries, possibly by acting as a K+ channel agonist, but it did not relax K+-induced contractions.

This study demonstrates that keratin K2 is crucial for proper keratinocyte structure and function in specific mouse skin areas, and its deficiency leads to cellular aggregates and skin abnormalities.

This study suggests that eruptive vellus hair cysts often have atypical pathological changes and likely originate from the infrainfundibulum and sebaceous duct based on keratin expression analysis.

This study observed that transgenic mice expressing keratin K10 under bovine K6beta control developed severe oral abnormalities, suggesting keratin composition changes can affect the physiology of epithelial cells, especially in the oral mucosa.

This study found that murine vibrissa hair follicle stem cells can be differentiated into corneal epithelial-like cells in vitro using limbus-specific microenvironmental factors, suggesting a potential therapeutic source for ocular surface disorders.

In this study, researchers identified the ventral matrix as the primary source of nail plate formation, while the dorsal portion is generated by the apical matrix.

This study discovered that a network controlled by the gene p63 is crucial for keratinocyte differentiation and is linked to MYC through cell adhesion-related pathways.

This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.

This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.

In this study, researchers found that contrary to expectations, keratin 10 domains did not reduce cell proliferation and instead increased tumor development in genetically modified mice.

Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.

This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.

This study reports that eccrine sweat glands in mice predominantly develop on the footpads, offering a reference for skin research involving genetically engineered mice.

This study found that miR-339-5p negatively regulates loureirin A-induced differentiation of hair follicle stem cells, potentially impacting skin repair and regeneration by inhibiting the Wnt/β-catenin signaling pathway.

This study shows that keratin 2e exhibits distinct temporal and regional expression patterns in fetal epidermis, suggesting different regulatory and functional roles from other epidermal keratins.

This study suggests that pilomatricoma can differentiate towards various hair follicle structures, including hair matrix, hair cortex, follicular infundibulum, outer root sheath, and hair bulge.

Human hair follicles have a unique cell distribution and differentiation pattern during growth.

This study found that keratoacanthoma of the lip likely arises from outer root sheath cells, based on the presence of specific keratin markers and periodic acid-Schiff staining patterns.

This study found that different types of seborrheic keratosis demonstrate diverse differentiation patterns, highlighting its undifferentiated and hyperproliferative state with varying keratinization directions.

Norfolk Terriers have a genetic skin defect causing scaling and blisters due to a keratin issue.

This study demonstrated that VD3 significantly enhanced the proliferation and differentiation of epidermal stem cells in a murine skin defect model, leading to improved wound healing, potentially through activation of the PI3K signaling pathway.

This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.

This study suggests that the expression patterns of keratin and filaggrin indicate milia may originate from the outermost cells of the hair bulge in the outer root sheath.

This study found that keratin K1014chim expression in mice did not reduce epidermal cell proliferation but increased susceptibility to benign tumors, challenging previous beliefs about K10's role in inhibiting tumor development.

This study found that cutaneous stem cells in the basal layer of fetal human skin contribute to the development of the epidermis and hair follicles, with specific marker expressions during different stages of skin development.

This study found that the distribution of hair keratin family proteins varies in normal scalp hair follicles, which may aid in identifying the origin of hair neoplasms.

This study found that full thickness wounds in Lanyu pigs led to altered molecular expression and abnormal skin structure, without regenerating key epithelial cells thought to aid in skin regeneration.

This review discusses changes in keratin structure or gene expression that result in various skin disorders and reports no new clinical findings.