Expression of Keratins K6 and K16 in Regenerating Mouse Epidermis Is Less Restricted by Cell Replication Than the Expression of K1 and K10

    July 1994 in “ PubMed ”
    Anders Heyden, Claus Lützow‐Holm, O. P. F. Clausen, P Brandtzæg, Henrik S. Huitfeldt
    TLDR Keratins K6 and K16 are expressed more freely in regenerating mouse skin than K1 and K10.
    The study investigated the expression of keratins K6 and K16 in regenerating mouse epidermis after applying the tumor promoter TPA. It was found that K6 and K16 were expressed differently compared to the typical keratins K1 and K10. K6 was induced in all epidermal layers, including replicating cells, and remained present throughout the observation period. In contrast, K16 appeared only in post-mitotic cells and was transiently expressed between 8-72 hours post-treatment. This suggested that K6 and K16 expression was less restricted by cell replication than K1 and K10, indicating a distinct role in epidermal regeneration.
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