Keratins 6, 16, And 17 In Health And Disease: A Summary Of Recent Findings

    Daniil Romashin, Tatiana Tolstova, Alexandra Varshaver … Natalia G. Luzgina
    Studysummary This review summarizes recent findings on keratins 6, 16, and 17, highlighting their role in keratinocyte behavior and nuclear functions, and discusses their potential as biomarkers for various skin pathologies, including damage, inflammation, and cancer, rather than in healthy skin.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 18

    1. Significance of Stress Keratin Expression in Normal and Diseased Epithelia iScience · 2024
    2. Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions International journal of molecular sciences · 2023
    3. Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    4. A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms International journal of molecular sciences · 2023
    5. The Immune Functions of Keratinocytes in Skin Wound Healing International Journal of Molecular Sciences · 2020
    6. Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses Journal of pathology · 2018
    7. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018
    8. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis Journal of Investigative Dermatology · 2015
    9. Comparative Anatomy of Mouse and Human Nail Units The Anatomical Record · 2013
    10. Keratins in Health and Cancer: More Than Mere Epithelial Cell Markers Oncogene · 2010
    11. Hedgehog Signaling, Keratin 6 Induction, And Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008
    12. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    13. Keratinocyte Differentiation in Psoriatic Scalp: Morphology and Expression of Epithelial Keratins British Journal of Dermatology · 2006
    14. Keratins of the Human Hair Follicle International review of cytology · 2005
    15. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    16. Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle Journal of Investigative Dermatology · 2002
    17. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    18. Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita Nature Genetics · 1995

    Related research 1

    1. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989