Keratins 6, 16, And 17 In Health And Disease: A Summary Of Recent Findings

August 2024 in “ Current Issues in Molecular Biology ”

Daniil Romashin, Tatiana Tolstova, Alexandra Varshaver, П. М. Кожин, А. Л. Русанов, Natalia G. Luzgina

keratins keratinocyte epidermis skin damage inflammation biomarkers keratinocyte migration keratinocyte proliferation nuclear structure DNA damage

TLDR Keratins 6, 16, and 17 increase in damaged or diseased skin and may help diagnose skin issues.

Keratins 6, 16, and 17 are not typically present in healthy epidermis but are upregulated in response to skin damage, inflammation, hereditary conditions, and cancer. They are being studied as potential biomarkers for these pathologies. Recent research highlights their roles in keratinocyte migration, proliferation, growth, and nuclear functions, such as maintaining nuclear structure and responding to DNA damage. This review compiles the latest findings on their regulation and potential diagnostic applications in skin conditions.

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Research cited in this study

17 / 17 results

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2 citations , December 2023 in “International journal of molecular sciences”

Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.

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3 citations , July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 17 is important for skin's response to radiation, affecting many genes and cell division.

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3 citations , March 2023 in “International journal of molecular sciences”

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

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Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

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Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

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Keratins are crucial for cell structure, growth, and disease risk.

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19 citations , December 2015 in “Journal of Investigative Dermatology”

The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.

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Mouse nails are similar to human nails, making them useful for studying nail diseases.

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Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

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Hedgehog signaling is essential for normal sebaceous gland development and affects keratin 6a expression.

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Keratins are crucial for cell stability, wound healing, and cancer diagnosis.

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63 citations , July 2006 in “British Journal of Dermatology”

Psoriasis causes changes in certain keratins and shrinks sebaceous glands in the scalp.

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More research is needed to understand how hair keratins work and their role in hair disorders.

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387 citations , November 2003 in “Journal of Investigative Dermatology”

The K15 promoter effectively targets stem cells in the hair follicle bulge.

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87 citations , November 2002 in “Journal of Investigative Dermatology”

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Keratin 17 is important for skin development and may help define skin cell types.

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research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

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