Hedgehog Signaling, Keratin 6 Induction, And Sebaceous Gland Morphogenesis

August 2008 in “ American Journal Of Pathology ”

Li-Hong Gu, Pierre A. Coulombe

Hedgehog signaling keratin 6a sebaceous gland morphogenesis Wnt signaling hair follicle regulation pachyonychia congenita

TLDR Hedgehog signaling is essential for normal sebaceous gland development and affects keratin 6a expression.

The study investigated the role of Hedgehog (Hh) signaling in sebaceous gland (SG) morphogenesis and its relationship with keratin 6a (K6a) expression using a mouse model. It found that Hh signaling was crucial for SG development, with increased Hh signaling leading to abnormal SGs with elongated ducts and increased K6a expression. This suggested that K6a could serve as a marker for ductal tissue in SGs. The research highlighted the potential regulatory role of Hh signaling in K6a expression and its implications for understanding appendageal defects in conditions like pachyonychia congenita. The study also noted the involvement of other pathways, such as Wnt signaling, in hair follicle and SG regulation, contributing to the understanding of skin and hair-related conditions.

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