Histogenesis of Keratoacanthoma: Histochemical and Immunohistochemical Study

October 2014 in “ Oral surgery, oral medicine, oral pathology and oral radiology ”

Vivian Petersen Wagner, Manoela Domingues Martins, Caroline Siviero Dillenburg, Luíse Meurer, Rogerio M. Castilho, Cristiane H. Squarize

keratoacanthoma immunohistochemical profiling histochemical profiling PAS K6 K10 K14 outer root sheath hair follicle cells

Studysummary This study found that keratoacanthoma of the lip likely arises from outer root sheath cells, based on the presence of specific keratin markers and periodic acid-Schiff staining patterns. Our plain-language summary of this paper — not a Tressless recommendation.

The study analyzed keratoacanthoma (KA) biopsies from the lips and normal skin samples using immunohistochemical and histochemical profiling to determine the origin of KA. The findings showed that KA tumor cells were positive for PAS, K6, K10, and K14, but not for hair cortex keratin, indicating that KA of the lip is derived from outer root sheath (ORS) cells, particularly those associated with the upper ORS. This suggested that KA arises from hair follicle cells, providing insight into its histogenesis.

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In this study, researchers observed that keratoacanthoma exhibits dynamic follicular differentiation throughout its stages, with changes in specific keratin expressions, and regressed lesions showing epidermal rather than follicular characteristics.

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research Human Hair Keratin-Associated Proteins

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research Keratins of the Human Hair Follicle

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More research is needed to understand how hair keratins work and their role in hair disorders.

research A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin

156 citations , January 1989 in “Genes & Development”

This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.

research The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins

198 citations , October 1986 in “Differentiation”

research The Keratoacanthoma: A Review

80 citations , January 1979 in “Journal of Surgical Oncology”

This paper reviews keratoacanthoma as a tumor that resembles but rarely progresses to squamous cell carcinoma, detailing its stages, potential origins, and distinguishing features from other similar growths, without reporting new clinical results.