Full Thickness Wound Healing in the Lanyu Pig

In this study, full-thickness wounding on Lanyu pigs led to scar formation and disrupted cell markers, while partial-thickness wounding allowed limited regeneration of rete ridges and papillary dermis.

This study characterizes the secondary hair follicles in the Lanyu pig, an indigenous breed sharing similarities with human vellus hair follicles, suggesting its relevance as a model for researching hair follicle-mediated skin regeneration and enhancing translation to human wound healing.

This study found that anagen skin in PVG rats showed significantly smaller wound diameters compared to telogen skin at 7 and 8 days after wounding, suggesting the importance of hair follicle dermal components in wound healing.

This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.

This study found that implanting hair follicle dermal sheath cells in rat skin wounds significantly accelerated wound contraction and healing compared to controls.