research Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma
Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.
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5 / 1000+ resultsresearch Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis
This study found that keratin 15 lacks the ability to sequester YAP1 in keratinocytes effectively, unlike keratin 14, and suggests that a higher K15:K14 ratio may promote a progenitor state and inhibit differentiation in epidermal keratinocytes.
research Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile
This study demonstrated that hair follicle bulge stem cells can form epidermis in a tissue-engineered skin model, highlighting the significance of K5/K17 filaments in slow-cycling stem cell subsets.
research Keratin expression by corneal and limbal stem cells during development
This review discusses cornea-specific keratin expression patterns in human and mouse development and reports no new experimental results; it highlights the need for investigating keratin mutations' role in pathology.
research Local Microenvironment Provides Important Cues for Cell Differentiation in Lingual Epithelia
This study used transgenic mice to show that disrupting TGF-β signaling in K14+ progenitor cells led to increased stem cell proliferation in the tongue.
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