The Hair Loss Encyclopedia

Biochemical and Immunohistochemical Analyses of Keratin Expression in Basal Cell Carcinoma

May 1998 in “ Journal of Dermatological Science ”

Kenichi Yoshikawa, Yohtaro Katagata, Shigeo Kondô

TLDR Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.

The study analyzed keratin expression in 8 cases of basal cell carcinoma (BCC) using biochemical and immunohistochemical methods. It found that stratified epithelial keratins K5/K14 and large amounts of K17 were present in all cases, while simple epithelial keratins K8 and K19 were expressed in all and half of the cases, respectively. Hyperproliferative keratins (K6/K16) and keratinized keratins (K1/K10) were detected in only a few cases. Immunohistochemical analysis showed BCC tumor cells reacted positively with antibodies against K8, K14, K17, and K19. The predominant expression of K17 and frequent expression of K8 and K19, with little K6/K16 and K1/K10 expression, suggested that BCC was differentiated towards undifferentiated follicular epithelia, likely hair bulge cells.

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Research cited in this study

10 / 10 results

research Immunohistochemical Localization of Cytokeratins and Involucrin in Calcifying Epithelioma: Comparative Studies with Normal Skin

49 citations , July 2006 in “British Journal of Dermatology”

Calcifying epithelioma cells can differentiate into hair cortex and outer root sheath.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research Keratin 17 Gene Expression During the Murine Hair Cycle

70 citations , March 1997 in “Journal of Investigative Dermatology”

research Characterization of Hair Follicle Bulge in Human Fetal Skin: The Human Fetal Bulge Is a Pool of Undifferentiated Keratinocytes

96 citations , December 1995 in “Journal of Investigative Dermatology”

research Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair Follicle Derived Tumors Compared to Nonfollicular Epithelial Skin Tumors

31 citations , March 1995 in “Journal of Investigative Dermatology”

research Keratin Expression in Basal Cell Carcinomas

128 citations , February 1992 in “British Journal of Dermatology”

Basal cell carcinomas likely originate from hair follicle cells or stem cells.

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues

124 citations , December 1988 in “Differentiation”

Trichocytic differentiation starts in cells with epithelial cytokeratins, transitioning to trichocytic cytokeratins in hair and gradually in nails.

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles

248 citations , April 1988 in “Differentiation”

Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.

research Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

277 citations , October 1982 in “The Journal of Cell Biology”

Basal-cell epitheliomas and the pilosebaceous tract share a unique keratin, distinguishing them from other skin areas.

Related Research

1 / 1 results

research Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

12 citations , January 1987 in “Carcinogenesis”

TCDD changes skin cell growth and keratin production in mice.