Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

    April 2014 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    H. Fischer, Lutz Langbein, Julia Reichelt … Leopold Eckhart
    Studysummary This study demonstrates that keratin K2 is crucial for proper keratinocyte structure and function in specific mouse skin areas, and its deficiency leads to cellular aggregates and skin abnormalities.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jidonline.org →
    Discuss this study in the Community →

    Research cited in this study 6

    1. The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia Current opinion in cell biology · 2012
    2. Keratin Disorders: From Gene to Therapy Human molecular genetics online/Human molecular genetics · 2011
    3. The Molecular Basis of Human Keratin Disorders Human Genetics · 2009
    4. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    5. Hair Keratins And Hair Follicle-Specific Epithelial Keratins Methods in cell biology · 2004
    6. Ontogeny and Regional Variability of Keratin 2e in Developing Human Fetal Skin: A Unique Spatial and Temporal Pattern of Keratin Expression in Development British Journal of Dermatology · 1999