Establishment of Keratinocyte Cell Lines from Human Hair Follicles

    September 2018 in “ Scientific reports ”
    Tanja Wagner, Maria Gschwandtner, Agata Strajeriu … Michael Mildner
    Studysummary This study demonstrates that keratinocyte cell lines derived from cultured hair follicles can fully differentiate in organotypic skin models, offering a minimally invasive alternative to obtaining keratinocytes for research.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 4

    1. A New Hair Follicle-Derived Human Epidermal Model for the Evaluation of Sunscreen Genoprotection Journal of photochemistry and photobiology. B, Biology · 2015
    2. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2014
    3. Ontogeny and Regional Variability of Keratin 2e in Developing Human Fetal Skin: A Unique Spatial and Temporal Pattern of Keratin Expression in Development British Journal of Dermatology · 1999
    4. Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells Journal of Investigative Dermatology · 1996