Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

    March 2020 in “ Frontiers in Cell and Developmental Biology ”
    T. Fukuda, Kazumasa Takahashi, Shin Takase … Tohru Kiyono
    Studysummary This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.
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    Research cited in this study 14

    1. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors Sexual medicine reviews · 2018
    2. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    3. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    4. Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells BMB Reports · 2010
    5. Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells BMB Reports · 2010
    6. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009
    7. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    8. Identification of Androgen-Regulated Genes in SV40-Transformed Human Hair Dermal Papilla Cells Journal of dermatological science · 2003
    9. Testosterone Metabolism in Human Skin Cells In Vitro and Its Interaction with Estradiol and Dutasteride Skin pharmacology and physiology · 2003
    10. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    11. Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model Journal of Investigative Dermatology · 2002
    12. Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia Expert Opinion on Investigational Drugs · 1999
    13. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996
    14. Culture of Hair Matrix and Follicular Keratinocytes Journal of Investigative Dermatology · 1993

    Related research 4

    1. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    2. Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray Journal of Dermatological Science · 2007
    3. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    4. Effects of Testosterone, Dihydrotestosterone and Estradiol on the Growth Behavior of Cultured Hair Bulb Papilla Cells and Root Sheath Fibroblasts 1989