Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

March 2020 in “ Frontiers in Cell and Developmental Biology ”

T. Fukuda, Kazumasa Takahashi, Shin Takase, Ai Orimoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Tohru Kiyono

immortalized dermal papilla cells androgen receptor androgenetic alopecia mutant CDK4 Cyclin D1 TERT K4DT retrovirus dihydrotestosterone DHT Dkk1 testosterone signaling pathway anti-testosterone drug MDV3100 DPCs AR AGA testosterone receptor

Studysummary This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.

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