Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells

    October 2010 in “ BMB Reports ”
    Mi-Hee Kwack, Ji-Sup Ahn, Moon-Kyu Kim … Young-Kwan Sung
    Studysummary In this study, L-threonate was observed to inhibit DHT-induced DKK-1 expression in dermal papilla cells and reverse DHT's inhibitory effects on outer root sheath cell growth, suggesting potential as a treatment for androgen-driven balding.
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    Research cited in this study 5

    1. L-Ascorbic Acid 2-Phosphate Represses Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Balding Dermal Papilla Cells Experimental Dermatology · 2010
    2. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    3. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002
    4. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    5. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995

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    3. Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells BMB Reports · 2010
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