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Glossary DNA methylation

chemical modification of DNA that can regulate gene expression

DNA methylation is a biological process where a methyl group is added to the DNA molecule, typically at cytosine bases. This modification can change the activity of a DNA segment without altering the sequence, often leading to gene silencing. It's a crucial mechanism in regulating gene expression and is involved in various processes, including development, aging, and disease.

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Research

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research Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

432 citations , April 2014 in “Nature communications”

This study found that the maternal nutritional status during early pregnancy significantly influenced epigenetic changes in offspring, as maternal diet altered DNA methylation at human metastable epialleles.

Evidence of Increased DNA Methylation of the Androgen Receptor Gene in Occipital Hair Follicles from Men with Androgenetic Alopecia

research Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

24 citations , March 2011 in “British Journal of Dermatology”

This study found evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia.

research Characterization of DNA Methylation and Screening of Epigenetic Markers in Polycystic Ovary Syndrome

9 citations , May 2021 in “Frontiers in Cell and Developmental Biology”

This study found that DNA methylation changes in granulosa cells from PCOS patients affect gene expression related to insulin resistance, fat cell differentiation, and steroid metabolism, suggesting an epigenetic contribution to PCOS pathogenesis.

research DNA methylation of microRNA-365-1 induces apoptosis of hair follicle stem cells by targeting DAP3

7 citations , March 2024 in “Non-coding RNA Research”

In this study using a mouse model, researchers found that DNA methylation of the miR-365-1 promoter plays a role in reducing apoptosis in hair follicle stem cells during chemotherapeutic alopecia.

research Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

7 citations , May 2021 in “EBioMedicine”

This study observed that aberrant DNA methylation in murine and human cutaneous squamous cell carcinoma likely contributes to the silencing of tumor suppressor genes, notably affecting the FILIP1L gene.

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community Anyone tried combining Finasteride and Ashwagandha?

4 upvotes 5 years ago

The conversation discusses using finasteride and ashwagandha for hair loss, with some users noting potential benefits and drawbacks. Minoxidil, peppermint oil, and creatine are also mentioned, with mixed opinions on their effectiveness.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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