Histochemical Studies on Cutaneous Stem Cells in Human Fetal Skin

January 2007 in “ Zhonghua shiyan waike zazhi ”

FU Xiao-bing

cutaneous stem cells human fetal skin epidermis hair follicles integrins β1 K19 K14 K10 epidermal progenitor cells PCNA basal layer mesenchymal cues

TLDR Basal layer skin cells help form the epidermis and hair follicles.

The study investigated the distribution and characteristics of cutaneous stem cells in human fetal skin during embryogenesis, using immunohistochemical methods to analyze their differentiation into epidermis and hair follicles. It found that integrins β1 and K19 were coexpressed in the undifferentiated epidermis, with β1 expression downregulated during follicular keratinization. K14 was differentially expressed in the basal and spinous layers, while K10 was in the differentiated spinous and granular layers. Epidermal progenitor cells were mainly located in the basal layer and hair follicle structures, expressing integrins β1, K19, K14, and PCNA. The study concluded that basal layer cutaneous cells contribute to epidermis and hair follicle development, with mesenchymal cues also playing a role in hair follicle formation and cycling.

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