Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals

    November 2018 in “ Molecular Biology and Evolution ”
    Florian Ehrlich, Heinz Fischer, Lutz Langbein … Leopold Eckhart
    Studysummary This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on academic.oup.com →
    Discuss this study in the Community →

    Research cited in this study 16

    1. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018
    2. Evolution of Trichocyte Keratins Advances in experimental medicine and biology · 2018
    3. A Curated Catalog of Canine and Equine Keratin Genes PLoS ONE · 2017
    4. Comparative Genomics Analyses of Alpha-Keratins Reveal Insights Into Evolutionary Adaptation of Marine Mammals Frontiers in Zoology · 2017
    5. A Keratin Scaffold Regulates Epidermal Barrier Formation, Mitochondrial Lipid Composition, And Activity The Journal of Cell Biology · 2015
    6. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2014
    7. Increased Rate of Hair Keratin Gene Loss in the Cetacean Lineage BMC Genomics · 2014
    8. Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity International review of cell and molecular biology · 2014
    9. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    10. Recurrent Functional Divergence of Early Tetrapod Keratins in Amphibian Toe Pads and Mammalian Hair Biology Letters · 2013
    11. Against The Rules: Human Keratin K80 Journal of Biological Chemistry · 2010
    12. Identification of Reptilian Genes Encoding Hair Keratin-Like Proteins Suggests a New Scenario for the Evolutionary Origin of Hair Proceedings of the National Academy of Sciences · 2008
    13. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    14. Terrestrial Vertebrates Have Two Keratin Gene Clusters; Striking Differences in Teleost Fish European Journal of Cell Biology · 2005
    15. Keratins of the Human Hair Follicle International review of cytology · 2005
    16. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004