Against The Rules: Human Keratin K80

September 2010 in “ Journal of Biological Chemistry ”

Lutz Langbein, Leopold Eckhart, Michael A. Rogers, Silke Praetzel‐Wunder, J. Schweizer

keratin K80 type II hair keratins intermediate filament desmosomal plaques alternative splicing K80.1 hair follicle epithelial tissues

TLDR Keratin K80 is an ancient protein found in various tissues, important for cell structure and tissue differentiation.

The study investigated human keratin K80 and its splice variant K80.1, revealing K80's unique expression across various epithelial tissues and its structural similarity to type II hair keratins. K80 was found in a wide range of epithelia, forming intermediate filaments with over 20 type I keratins, and was notably present in hair follicles. K80.1 was more restricted, primarily detected in hair follicles and tongue papillae. The research highlighted K80's evolutionary significance, being one of the oldest keratins, and the novel occurrence of alternative splicing in keratins. The study emphasized K80's role in epithelial differentiation and its potential importance in hair follicle biology.

View this study on jbc.org →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle

87 citations , July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

326 citations , February 2009 in “The American journal of pathology”

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

research Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair

115 citations , November 2008 in “Proceedings of the National Academy of Sciences”

Reptiles have genes similar to hair proteins, suggesting hair's genetic origins predate mammals.

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

research Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13

92 citations , February 2005 in “Journal of Investigative Dermatology”

research Keratins of the Human Hair Follicle

276 citations , January 2005 in “International review of cytology”

More research is needed to understand how hair keratins work and their role in hair disorders.

The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

70 citations , December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Hair Keratins and Hair Follicle–Specific Epithelial Keratins

31 citations , January 2004 in “Methods in cell biology”

Hair and follicle keratins differ in structure and expression, especially in cysteine content.

research K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1

130 citations , April 2003 in “Journal of Investigative Dermatology”

Four specific keratins in hair follicles help understand hair structure and function.

research The Catalog of Human Hair Keratins

235 citations , July 1999 in “Journal of biological chemistry/The Journal of biological chemistry”

Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.

research A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform

28 citations , December 1997 in “Journal of Biological Chemistry”

A genetic mutation in the hHa1 gene creates a smaller, but still functional, hair protein without causing hair problems.

Similar Research

5 / 1000+ results

Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis

Against The Rules: Human Keratin K80

Research cited in this study

research The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle

research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

research Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

research Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13

research Keratins of the Human Hair Follicle

research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research Hair Keratins and Hair Follicle–Specific Epithelial Keratins

research K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1

research The Catalog of Human Hair Keratins

research A Splice Site Mutation in the Gene of the Human Type I Hair Keratin hHa1 Results in the Expression of a Tailless Keratin Isoform

Related Community Posts Join

community Keratin fibers vs. Gossypium Herbaceum Hair fibers

community Keratin microspheres - breakthrough

community Discussion: Keratin Microsphere Results

community Keratin fibers helped me to combat the cosmetic effect of hair loss

community Let's talk keratin products and hair loss

community Is Biotin or Keratin shampoo better for hair health/growth

Similar Research

research Keratin Function and Regulation in Tissue Homeostasis and Pathogenesis

research Characteristics of KRT80 and Its Roles in Neoplastic Diseases

research Keratin Intermediate Filaments in the Colon: Guardians of Epithelial Homeostasis

research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity

research Complete Structure of an Epithelial Keratin Dimer: Implications for Intermediate Filament Assembly