Characteristics of KRT80 and Its Roles in Neoplastic Diseases
May 2023
in “
Cancer medicine
”
TLDR KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.
The document discusses the role of KRT80, a human type II epithelial keratin gene, in various types of cancer. KRT80 is overexpressed in many neoplasms, promoting cell proliferation, migration, and invasiveness, leading to poor prognosis in cancer patients. It is highly expressed in several cancers, including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), colorectal carcinoma (CRC), non-small-cell lung cancer (NSCLC), ovarian cancer (OC), and endocrine-resistant breast cancer (BC). In some cancers, higher KRT80 expression is linked to poorer disease-free survival (DFS) and overall survival (OS), while in others, the correlation is unclear. The role of KRT80 is mediated through various pathways, including the circPIP5K1A-miR-671-5p-KRT80 axis, the PI3K/AKT pathway, and the MEK/ERK pathway. The document suggests that KRT80 has potential as a new cancer marker and therapeutic target, but more in-depth studies are needed.
