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Research

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research Skipping of Exons by Premature Termination of Transcription and Alternative Splicing within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant

6 citations , June 2012 in “PloS one”

This study identified a novel SCF mRNA splice variant in white merino sheep skin, which may play a role in hair follicle melanogenesis.

research 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This commentary discusses the crucial role of the alternative splicing factor Esrp1 in maintaining skin barrier function and its association with skin diseases like atopic dermatitis and psoriasis, but reports no new clinical results.

research Against the Rules: Human Keratin K80

40 citations , September 2010 in “Journal of Biological Chemistry”

This study found that keratin K80, structurally similar to hair keratins, is broadly expressed in various epithelial tissues and is involved in intermediate filament formation with multiple type I partners.

research Cellular Senescence and Aging in Myotonic Dystrophy

4 citations , February 2022 in “International Journal of Molecular Sciences”

This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.

research Comparative Skin Transcriptomics Reveals Key Regulators of Cashmere Fiber Production in Inner Mongolian Goats

March 2026 in “Animals”

In this study, researchers used transcriptome sequencing to identify 1543 differentially expressed genes between cashmere and normal goats, implicating several signaling pathways and key regulators in the distinct gene expression profiles linked to cashmere fiber production, which advances understanding of cashmere goat genetics.

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Community Join

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community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Alternative keto shampoo to nizoral?

in Ketoconazole 4 upvotes 1 year ago

The conversation is about finding an alternative ketoconazole shampoo to Nizoral due to its strong smell, with suggestions including Intelligent shampoo and Sons brand. The discussion also touches on the effectiveness of ketoconazole for dandruff and hair loss, with some users recommending prescription options for higher concentrations.

community Alternative to nizoral

6 upvotes 5 years ago

The conversation is about finding alternatives to Nizoral for dandruff treatment. Suggestions include coconut oil, Regenepure DR, apple cider vinegar, Mg217, and zinc pyrithione-based shampoos.

community Alternative to Hims Shampoo

6 years ago

OP is seeking a cheaper alternative to Hims shampoo, praising its conditioning and eucalyptus scent. A user suggests Hair Restoration Laboratories as an option.

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Learn

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learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

learn Hair Transplant

What are the non-surgical alternatives to hair transplants? Non-surgical alternatives include PRP therapy, medications, laser therapy, and scalp micropigmentation.

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Finasteride

Is Finasteride unbeatable or are there equally powerful alternatives? Trials report finasteride as the single medication with the strongest measured effect in male androgenetic alopecia, while dutasteride, minoxidil, topical finasteride, PRP, LLLT and microneedling all have supporting studies and are often reported to work better in combination. Finasteride, dutasteride and oral minoxidil are prescription-only, and several of these uses are off-label.

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Clinics

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