Comparative Genomics Analyses of Alpha-Keratins Reveal Insights Into Evolutionary Adaptation of Marine Mammals

    August 2017 in “ Frontiers in Zoology ”
    Xiaohui Sun, Zepeng Zhang, Yingying Sun … Guang Yang
    Studysummary In this study, the researchers reported extensive gene loss and high pseudogenization rates of α-keratin genes in cetaceans compared to terrestrial mammals, likely linked to hair loss and aquatic adaptations.
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    Research cited in this study 12

    1. Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments BMC genomics · 2014
    2. Autosomal Recessive Transmission of a Rare KRT74 Variant Causes Hair and Nail Ectodermal Dysplasia: Allelism with Dominant Woolly Hair/Hypotrichosis PLoS ONE · 2014
    3. Increased Rate of Hair Keratin Gene Loss in the Cetacean Lineage BMC Genomics · 2014
    4. Molecular Evolution of the Keratin Associated Protein Gene Family in Mammals: Role in the Evolution of Mammalian Hair BMC Evolutionary Biology · 2008
    5. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    6. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    7. Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007
    8. Human Hair Keratin-Associated Proteins ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2005
    9. Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency Journal of Investigative Dermatology · 2003
    10. Why Mammal Body Hair Is an Evolutionary Enigma 2003
    11. Is Loose Anagen Hair Syndrome a Keratin Disorder? Archives of Dermatology · 2002
    12. Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b The Journal of Cell Biology · 2001