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research Comparative genomics analyses of alpha-keratins reveal insights into evolutionary adaptation of marine mammals

25 citations , August 2017 in “Frontiers in Zoology”

In this study, the researchers reported extensive gene loss and high pseudogenization rates of α-keratin genes in cetaceans compared to terrestrial mammals, likely linked to hair loss and aquatic adaptations.

research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

96 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

research DEVELOPMENTAL AND EVOLUTIONARY COMPARATIVE ANALYSIS OF A REGULATORY LANDSCAPE IN MAMMALS AND BIRDS

2 citations , August 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study observed that distinct subsets of Hoxd genes in murine vibrissae and chicken feather primordia are regulated by different lineage-specific enhancers, indicating evolutionary changes in chromatin topology contribute to transcriptional robustness.

research A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea

15 citations , June 2019 in “eLife”

This study identified Activin A and follistatin as key regulators of hair cell differentiation in the mammalian auditory sensory epithelium, with Activin A signaling influencing the timing and pattern of cell differentiation.

research Bone morphogenetic protein signaling drives rete ridge morphogenesis: a distinct epidermal appendage program

May 2026 in “Signal Transduction and Targeted Therapy”

This study found that rete ridge morphogenesis in mammalian skin is directed by a BMP-dependent developmental program, which is evolutionarily distinct from other known pathways controlling the development of hair follicles, sweat glands, and fingerprint ridges.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Mature hairlines in general and defining them

13 upvotes 4 years ago

A "mature hairline" is subjective and may not indicate future stability. Finasteride and minoxidil are suggested treatments for hair loss.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Male 23 kya topical minoxidil 18 mahine tak istemaal karne ke baad result nahi mila to mujhe oral minoxidil istemaal karna chahiye agar karna chahiye to kitna mg se chaalu kare

2 weeks ago

A user is considering switching from topical to oral minoxidil after 18 months without results, with suggestions to start at 1.25 mg twice daily. Another user shared success with 0.5 mg finasteride nightly and 1.25 mg minoxidil in the morning, suggesting adjusting doses based on results.

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