Increased Rate of Hair Keratin Gene Loss in the Cetacean Lineage

    January 2014 in “ BMC Genomics ”
    Mariana F. Nery, José Ignacio Arroyo, Juan C. Opazo
    Studysummary This study highlights the loss of hair-type keratin genes in cetaceans compared to terrestrial mammals, suggesting a potential adaptive role linked to their hairless phenotype and habitat changes.
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    Research cited in this study 12

    1. Mammalian Keratin-Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments BMC genomics · 2014
    2. Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans BMC evolutionary biology · 2013
    3. Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes: Enlarged Medulla, Loss of Cuticle, and Long Catagen Hirosaki University Repository for Academic Resources (Hirosaki University) · 2009
    4. Identification of Reptilian Genes Encoding Hair Keratin-Like Proteins Suggests a New Scenario for the Evolutionary Origin of Hair Proceedings of the National Academy of Sciences · 2008
    5. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    6. The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-Kb Genomic DNA Containing Five Basic Keratin Genes Journal of Biological Chemistry · 2008
    7. The Organization of the Keratin I and II Gene Clusters in Placental Mammals and Marsupials Show a Striking Similarity European Journal of Cell Biology · 2005
    8. The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    9. Dermo-Epidermal Interactions in Reptilian Scales: Speculations on the Evolution of Scales, Feathers, and Hairs Journal of experimental zoology. Part B, Molecular and developmental evolution · 2004
    10. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    11. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 Journal of biological chemistry/˜The œJournal of biological chemistry · 2001
    12. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999