68 citations
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November 2018 in “Molecular Biology and Evolution” This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.
1 citations
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May 2015 in “Experimental Dermatology” This study found that constitutive activation of Stat3 in transgenic mice led to impaired hair growth and structural disorganization due to aberrant regulation of hair follicle and cytoskeletal genes.
482 citations
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June 1979 in “Proceedings of the National Academy of Sciences” This study demonstrated that keratin is widely present in various epithelial cells, providing structural strength and potential insights into the origin of cell lines.
12 citations
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May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.
7 citations
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March 2020 in “PloS one” This study demonstrates that α-parvin is crucial for epidermal morphogenesis and hair follicle development by mediating integrin-dependent adhesion and actin organization in keratinocytes.