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GlossaryKeratin 2 (K2)

protein providing structural strength to skin, hair, and nails

Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

research Ontogeny and Regional Variability of Keratin 2e in Developing Human Fetal Skin: A Unique Spatial and Temporal Pattern of Keratin Expression in Development

19 citations , April 1999 in “British Journal of Dermatology”

Keratin 2e shows a unique pattern in developing fetal skin, different from other keratins.

research A Homozygous Missense Variant in K25 Underlying Overlapping Phenotype With Woolly Hair and Dental Anomalies

2 citations , August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific mutation in the K25 gene causes a rare genetic disorder with curly hair at birth and later hair loss, along with dental issues.

research Construction of Cashmere Goat Embryos Carrying K2.9 Gene by Transgenic Somatic Cell Nuclear Transfer Technology

January 2012 in “Zhongguo nongye Kexue”

The technology can create transgenic cashmere goats with improved wool quality.

research Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

32 citations , April 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Loss of keratin K2 causes skin problems and inflammation.

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community Looking for suggestions on vitamins

in Female 6 upvotes 1 year ago

A user is seeking affordable hair vitamins without biotin, already taking zinc and D3+K2, and has been dealing with chronic telogen effluvium since 2013. They previously used Nutrafol Vegan but found it too expensive.

community Does this look like progress? 4mo on treatment.

in Progress Pictures 3 upvotes 2 months ago

The user is 4 months into using a treatment with 5mg Dutasteride and 1.25mg Minoxidil daily, along with vitamin K2 and weekly dermastamping. They report some hairline improvement but no noticeable change in the crown area yet.

community 8 months progress on min & fin

in Progress Pictures 148 upvotes 3 months ago

The user reported 8 months of hair regrowth progress using 2.5mg oral minoxidil and 0.025% topical finasteride, with no side effects. They also use Keto shampoo and vitamin D3+K2 supplements.

community Glad I took treatment. (Dut, fin,min, microneedling)

in Progress Pictures 11 upvotes 3 months ago

The user is using a hair loss treatment involving dutasteride, minoxidil, finasteride, microneedling, and supplements like multivitamins, D3 K2, and Omega 3 fish oil. They are considering adding tretinoin and are open to suggestions while managing gut issues.

community Experiences with topical Finasteride (0.0125%)?

in Finasteride/Dutasteride 7 upvotes 4 months ago

A 23-year-old male with slight hair thinning is using ketoconazole shampoo, biotin, zinc, magnesium, D3/K2, and has just started topical finasteride (0.0125%). He plans to add minoxidil (4.5%) with 17α-estradiol and is seeking advice on the effectiveness and side effects of these treatments, as well as the use of a dermaroller.

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