Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells Into Corneal Epithelial-Like Cells

    December 2008 in “ Stem Cells ”
    E. A. Blazejewska, Ursula Schlötzer‐Schrehardt, Matthias Zenkel … Friedrich E. Kruse
    Studysummary This study found that murine vibrissa hair follicle stem cells can be differentiated into corneal epithelial-like cells in vitro using limbus-specific microenvironmental factors, suggesting a potential therapeutic source for ocular surface disorders.
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    Research cited in this study 14

    1. Multipotent Hair Follicle Stem Cells Promote Repair of Spinal Cord Injury and Recovery of Walking Function Cell Cycle · 2008
    2. Vibrissa Hair Bulge Houses Two Populations of Skin Epithelial Stem Cells Distinct by Their Keratin Profile ˜The œFASEB journal · 2007
    3. Neural Potential of a Stem Cell Population in the Hair Follicle Cell Cycle · 2007
    4. Hair Follicle Stem Cells: Walking the Maze European Journal of Cell Biology · 2007
    5. The Potential of Nestin-Expressing Hair Follicle Stem Cells in Regenerative Medicine Expert Opinion on Biological Therapy · 2007
    6. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    7. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    8. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    9. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004
    10. Transdifferentiation of Corneal Epithelium: Evidence for a Linkage Between the Segregation of Epidermal Stem Cells and the Induction of Hair Follicles During Embryogenesis The International Journal of Developmental Biology · 2004
    11. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003
    12. Hair Follicle Stem Cells: Insights from the 2003 Workshop ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    13. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    14. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000

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