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    Glossary DNA damage response

    cellular mechanisms detect and repair damaged DNA to maintain integrity

    The DNA damage response (DDR) is a complex network of cellular processes that detect and repair damage to the DNA, ensuring the integrity of the genetic material. When DNA is damaged by factors like UV radiation or chemicals, DDR mechanisms activate to either fix the damage or, if repair is not possible, trigger cell death to prevent the propagation of faulty DNA. This system is crucial for preventing mutations that could lead to diseases such as cancer.

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    1. DNA Damage Response Mediates Pressure Overload–Induced Cardiomyocyte Hypertrophy Circulation · 2019 · 42 citations
    2. Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation 2012
    3. DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells Else Kröner-Fresenius Symposia · 2012
    4. Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes The Journal of Steroid Biochemistry and Molecular Biology · 2026
    5. LH Induces Murine Hair Loss through TRPC-Medicated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis Journal of Investigative Dermatology · 2025
    6. Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    7. Montagna Symposium 2013—Light and Skin: How Light Sustains, Damages, Treats, Images and Modifies Skin Biology 2014 · 1 citations
    8. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009 · 53 citations
    9. Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model Frontiers in Immunology · 2020 · 48 citations
    10. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
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    Community 1 of 13

    1. Prevention of age-related beard graying in humans by the topical application of Eriodictyon angustifolium extract Reddit · 8 Sept 2022
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