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Glossary DNA damage response

cellular mechanisms detect and repair damaged DNA to maintain integrity

The DNA damage response (DDR) is a complex network of cellular processes that detect and repair damage to the DNA, ensuring the integrity of the genetic material. When DNA is damaged by factors like UV radiation or chemicals, DDR mechanisms activate to either fix the damage or, if repair is not possible, trigger cell death to prevent the propagation of faulty DNA. This system is crucial for preventing mutations that could lead to diseases such as cancer.

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research DNA Damage Response Mediates Pressure Overload–Induced Cardiomyocyte Hypertrophy

42 citations , February 2019 in “Circulation”

This study observed that DNA damage response (DDR) plays a key role in pressure overload-induced cardiomyocyte hypertrophy, with disruption of the ATM kinase pathway potentially modulating this hypertrophy in mice.

research Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation

January 2012

This study found that Mdm2 is critical for limiting p53 activity to maintain normal stem cell function in mouse skin, with impacts on tissue homeostasis and aging.

research DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells

January 2012 in “Else Kröner-Fresenius Symposia”

This symposium reported that DNA damage accumulation in aging stem cells affects genome integrity, highlighting novel mechanisms like Bmi1's role in DNA repair and the involvement of BATF in lymphoid differentiation.

research Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes

March 2026 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that mice lacking both vitamin D and calcium-sensing receptors in epidermal keratinocytes are predisposed to developing squamous cell carcinoma as they age, due to impaired oxidative stress response and reduced DNA repair capabilities.

LH Induces Murine Hair Loss Through TRPC-Mediated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis

research LH Induces Murine Hair Loss through TRPC-Medicated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis

April 2025 in “Journal of Investigative Dermatology”

This study found that elevated luteinizing hormone levels were significantly associated with female pattern hair loss, and implicated LH/LHR signaling in the aging and damage of hair follicles.

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community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 2 years ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Anyone try GHK-Cu ?

4 upvotes 7 years ago

GHK-Cu is discussed for its potential anti-aging and healing properties, with some users considering its effects on hair growth. One user mentions using Folligen Spray and topical finasteride, noting improved healing but uncertain hair growth results.

community Tried my best to learn the genetics of male pattern balding

2 upvotes 3 months ago

Male pattern balding is influenced by genetic mutations on several chromosomes, affecting DHT sensitivity, hair pattern, and follicle resilience. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Homeless man always wins in this one

1262 upvotes 1 month ago

Hair loss and its potential links to genetics, mental health, and lifestyle factors. Treatments like Minoxidil, finasteride, and RU58841 are not mentioned in the conversation.

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learn Epidermal Growth Factor

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