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GlossaryAtaxia Telangiectasia and Rad3-related protein

enzyme ATR detects DNA damage and activates repair mechanisms

Ataxia Telangiectasia and Rad3-related protein, commonly known as ATR, is a crucial enzyme involved in the cellular response to DNA damage. It helps maintain genomic stability by detecting DNA damage and activating repair pathways, thus preventing mutations that could lead to diseases like cancer.

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research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

Dermal factors are crucial in regulating melanin production in skin.

research Germline Mutation in ATR in Autosomal-Dominant Oropharyngeal Cancer Syndrome

71 citations, February 2012 in “The American Journal of Human Genetics”

A specific ATR gene mutation is linked to a hereditary oropharyngeal cancer syndrome.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations, June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

research Molecular Mechanisms of Viral Oncogenesis in Humans

141 citations, August 2018 in “Nature Reviews Microbiology”

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

research Human Skin Stem Cells and the Aging Process

143 citations, September 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.