Comparative Histological and Immunohistochemical Study on the Effect of Platelet-Rich Plasma and Minoxidil, Alone or in Combination, on Hair Growth in a Rat Model of Androgenic Alopecia

    January 2022 in “ Tissue & Cell ”
    Sara Abdel Gawad Elsebay, Hoda A. Nada, Nancy Sultan, Dalia Alaa El-Din Aly El-Waseef
    Studysummary This study found that platelet-rich plasma was more effective than minoxidil in treating androgenic alopecia in rats, with the best results observed when both treatments were combined.
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    Research cited in this study 33

    1. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    2. Comparison of Efficacy of Platelet-Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male-Type Baldness: A Randomized, Double-Blind Placebo Control Trial Indian Journal of Dermatology, Venereology and Leprology · 2019
    3. A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women Dermatologic Surgery · 2019
    4. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    5. Platelet-Rich Plasma for Treating Androgenic Alopecia: A Systematic Review Aesthetic Plastic Surgery · 2019
    6. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    7. Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation Biomedicines · 2019
    8. Efficacy and Safety of a New 5% Minoxidil Formulation in Male Androgenetic Alopecia: A Randomized, Placebo-Controlled, Double-Blind, Noninferiority Study Journal of Cosmetic Dermatology · 2018
    9. Efficacy of Subcutaneous Injection of Platelet-Rich Plasma in Alopecia: A Clinical and Histological Pilot Study on a Rat Model with a Six-Month Long-Term Follow-Up Experience Journal of Cosmetic Dermatology · 2017
    10. Platelet-Rich Plasma Stimulates Angiogenesis in Mice Which May Promote Hair Growth European Journal of Medical Research · 2017
    11. Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature Stem cell investigation · 2017
    12. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss Stem cell investigation · 2017
    13. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    14. Androgenetic Alopecia: A Review Endocrine · 2017
    15. The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study Dermatologic Surgery · 2017
    16. Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems International Journal of Molecular Sciences · 2017
    17. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia Dermatologic Surgery · 2016
    18. Management of Androgenetic Alopecia: A Comparative Clinical Study Between Plasma Rich in Growth Factors and Topical Minoxidil European Journal of Plastic Surgery · 2016
    19. The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial Stem Cells Translational Medicine · 2015
    20. Selected Disorders of Skin Appendages: Acne, Alopecia, Hyperhidrosis Medical Clinics of North America · 2015
    21. The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation BioMed Research International · 2014
    22. Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool Journal of Cutaneous and Aesthetic Surgery · 2014
    23. Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period Journal of Cutaneous and Aesthetic Surgery · 2014
    24. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    25. Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth Dermatologic Surgery · 2011
    26. Effects of Topical Application of EGCG on Testosterone-Induced Hair Loss in a Mouse Model Experimental Dermatology · 2011
    27. Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations Acta Histochemica Et Cytochemica · 2010
    28. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    29. Follicular Streamers (Stelae) in Scarring and Non-Scarring Alopecia Journal of Cutaneous Pathology · 2008
    30. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    31. Histological Features of Peripilar Signs Associated with Androgenetic Alopecia Archives of Dermatological Research · 2004
    32. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    33. The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness Clinics in Dermatology · 1988

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