Nitric Oxide Donor and Minoxidil Co-Loaded Microneedles Improving Hair Loss Treatment

    August 2025 in “ Macromolecular Bioscience ”
    Xueyang Wang, Xiao‐Jie Ju, Chunyan He
    Studysummary This study found that microneedles co-delivering minoxidil and a nitric oxide donor effectively promoted hair growth and follicle transition to the growth phase in an alopecia mouse model, suggesting a promising new approach for androgenetic alopecia treatment.
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    Research cited in this study 21

    1. Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review ACS Materials Au · 2024
    2. In Situ Formed Fluorescent Gold Nanoclusters Inhibit Hair Follicle Regeneration in Oxidative Stress Microenvironment via Suppressing NFκB Signal Pathway Chinese Chemical Letters · 2024
    3. Nanotechnology-Based Techniques for Hair Follicle Regeneration Biomaterials · 2023
    4. Nitric Oxide Synergizes Minoxidil Delivered by Transdermal Hyaluronic Acid Liposomes for Multimodal Androgenetic Alopecia Therapy Bioactive Materials · 2023
    5. Follicle-Targeted Delivery of Betamethasone and Minoxidil Co-Entrapped in Polymeric and Lipid Nanoparticles for Topical Alopecia Areata Treatment Pharmaceuticals · 2023
    6. Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications Advanced Science · 2023
    7. Advances in Microneedles Research Based on Promoting Hair Regrowth Journal of Controlled Release · 2022
    8. Protac Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration Small methods · 2022
    9. Exploiting Recent Trends in the Treatment of Androgenic Alopecia Through Topical Nanocarriers of Minoxidil Aaps Pharmscitech · 2022
    10. Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders Asian Journal of Pharmaceutical Sciences · 2022
    11. The Inflammatory Component of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    12. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    13. An Appraisal of Laboratory Models of Androgenetic Alopecia: A Systematic Review Skin health and disease · 2021
    14. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    15. Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia Artificial Cells Nanomedicine and Biotechnology · 2016
    16. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    17. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    18. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    19. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    20. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
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