Continued Year-On-Year Improvement in Hair Density With Systemic Minoxidil in Women With Female Pattern Hair Loss: A Case Series

March 2025 in “ Journal of the American Academy of Dermatology ”

Daniella Kushnir -Grinbaum, Daranporn Triwongwaranat, Bevin Bhoyrul, John Frewen, Nicole Yoong, Blake R. C. Smith, Rodney Sinclair

systemic minoxidil female pattern hair loss Sinclair grade facial hypertrichosis Rogaine FPHL

TLDR Systemic minoxidil improves hair density in women with female pattern hair loss over time.

This retrospective study evaluated the long-term efficacy of systemic minoxidil in treating female pattern hair loss (FPHL) in 51 women over at least 3 years, with 34 having 5-year follow-up data. The study found that after 5 years, 64.7% of patients achieved a 1-point reduction in Sinclair grade (SG), indicating improved hair density, while 29.4% maintained stable SG. The 7-point scale showed significant improvement in midline hair density after 1 year (P = .017). Side effects included facial hypertrichosis in 45% of patients. The study suggests that systemic minoxidil leads to stabilization or improvement in hair density over time, although it is limited by its retrospective design, small sample size, and lack of a control group.

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