In Vivo and In Silico Evaluation of the Ameliorative Effect of Hesperidin on Finasteride-Induced Testicular Oxidative Stress in Wistar Rats
October 2020
in “
Toxicology Mechanisms and Methods
”
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Studysummary This study found that in male rats, hesperidin co-administration ameliorated finasteride-induced testicular toxicity by reducing oxidative stress and improving antioxidant status, sperm parameters, and enzyme activity compared to finasteride treatment alone.
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Hesperidin, a flavonoid found in citrus fruits, has been found to protect against testicular oxidative stress caused by finasteride in Wistar rats. The study suggests that hesperidin may have a protective effect against finasteride-induced testicular damage, improve sperm count and motility, and reduce abnormal sperm in male rats. Hesperidin was found to have a better binding affinity for 5a-reductase than finasteride. The compound may also have potential as a 5AR inhibitor, but further research is required to confirm this.
