Cutaneous Syndromes Produced as Side Effects of Triparanol Therapy

The document reports on the side effects of triparanol therapy, which include hair loss and ichthyosis. Hair loss appeared 2 to 8 weeks after cessation of triparanol and was of the telogen type, without scalp inflammation or pathological changes in the hair follicles. Additionally, hair color lightened without a clear relationship to dosage or duration of treatment. Ichthyosis occurred independently of the dosage or length of administration and was characterized by marked hyperkeratosis but normal epithelium and adnexal structures in skin biopsies. The study suggests that triparanol's inhibition of cholesterol synthesis may impact epithelial cell integrity and pigmentation, and that these side effects provide a model for studying artificially induced disease and its relevance to skin disease research.