Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis
TRPV3 channel keratinocytes epidermal barrier formation hair follicle growth keratinocyte-mediated inflammation cutaneous itch pain sensation gain of function mutations Olmsted syndrome keratinocyte hyperproliferation cryo-EM heat-activated state wild type resting state S6 domain TRP box domain W692G mutation hyperkeratosis molecular dynamic simulation skin barrier hair growth skin inflammation itch pain mutation skin cell overgrowth cryogenic electron microscopy heat activation resting state S6 segment TRP box W692G thickened skin molecular dynamics
Studysummary This study suggests that structural changes in the TRPV3 channel are linked to severe skin conditions like Olmsted syndrome, with differences observed between heat-activated and resting states.
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