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research Painful thickened skin on the soles of the feet

September 2022 in “JAAD case reports”

This case study of a 45-year-old man from Tonga describes the identification of pachyonychia congenita through genetic testing, revealing a mutation in the keratin gene KRT16, associated with chronic painful skin and nail conditions.

research Obesity and the skin

128 citations , September 2011 in “British Journal of Dermatology”

Obesity is linked to various skin problems and may increase the risk of skin cancer.

research Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice

81 citations , February 2014 in “EMBO molecular medicine”

This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

research Cutaneous Ultrastructural Features of the Flaky Skin (fsn) Mouse Mutation

28 citations , June 1995 in “The Journal of Dermatology”

This study reports that flaky skin mice exhibit skin and nail features that closely resemble human psoriasis vulgaris, suggesting they may serve as a natural model for this condition.

research Correction: RASopathic Skin Eruptions during Vemurafenib Therapy

4 citations , October 2013 in “PLoS ONE”

This study found that Vemurafenib led to a broad range of cutaneous side effects in nearly all patients with advanced melanoma, highlighting the need for regular dermatologic management and UV protection.

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community Anybody else notice improved skin/collagen on Dutasteride

6 upvotes 3 years ago

User switched from finasteride to combination dutasteride and finasteride for hair density improvement. They noticed less hair shedding and more youthful skin, with a reply suggesting less DHT could increase elastin in skin.

community How have you thickened your beard on finasteride. B4/After pics too

61 upvotes 1 year ago

Finasteride can slow beard growth, but minoxidil and dermarolling may enhance beard thickness. Minoxidil is suggested for permanent beard gains, while finasteride is mainly for scalp hair maintenance.

community Hair texture very thin anything that would help long hair to thicken?

4 upvotes 3 years ago

The user is seeking ways to thicken their fine, thin hair and is considering treatments like spironolactone, minoxidil, and microneedling. They are currently using oral spironolactone, topical minoxidil, and ketoconazole shampoo, and are exploring additional options like alfatradiol and adjusting their treatment regimen.

community Hair Loss and Oily Skin: Blocking DHT Helps

in Research/Science 8 upvotes 7 months ago

Lowering DHT can improve skin quality and reduce scalp issues. Finasteride is effective for hair regrowth and improving skin texture, while dutasteride may increase oiliness and shedding for some users.

community Current regimen: Topical finasteride 0.3% Minoxidil 6% once daily. 5 months. Also just started taking Zinc 20MG daily. Saw Palmetto 450mg daily. Hair, skin & nails supplements (includes a bunch of vitamins essential for hair skin and nails) Was debating on adding oral finasteride. Thoughts?

in Finasteride/Dutasteride 6 upvotes 1 year ago

The user is using a regimen of topical finasteride 0.3% and minoxidil 6% daily, along with zinc, saw palmetto, and hair supplements, but is unsure about the results and considering adding oral finasteride. Other users share mixed experiences with similar treatments, suggesting patience or switching to oral forms.

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