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Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that structural changes in the TRPV3 channel are linked to severe skin conditions like Olmsted syndrome, with differences observed between heat-activated and resting states.

research How a Bird Gets Its Feathers: Insights from Chromatin Looping

3 citations , June 2020 in “Developmental Cell”

This study observed that in chicken skin, large-scale differences in gene expression between feathered and scaly skin are controlled by enhancer-driven uniform expression, while small-scale differences within individual feathers are associated with chromatin looping.

research Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing

1 citations , January 2024 in “Fibrosis”

This review examines advancements in hydrogel formulations aimed at preventing dermal fibrosis and promoting scarless wound healing, highlighting their role in regulating myofibroblast differentiation and controlling the wound microenvironment.

research Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole

28 citations , September 2021 in “EMBO reports”

In this study, researchers used cryo-electron microscopy to reveal how the natural compound osthole inhibits TRPV3 channels by binding to specific sites, changing the channel's conformation.

research Challenges in the Physical Characterization of Lipid Nanoparticles

92 citations , April 2021 in “Pharmaceutics”

This review discusses the applications and challenges of lipid nanosystems in various fields, comparing techniques for evaluating nanoparticle properties, and reports no new experimental results.

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community When is the cure gonna drop , how much more time

in Research/Science 112 upvotes 6 months ago

There is no imminent cure for hair loss, but treatments like Minoxidil, Finasteride, and new drugs such as KX-826, GT-20029, and PP405 are being explored. Current solutions focus on slowing hair loss and stimulating growth, with hopes for better options in the future.

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