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Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

research How a Bird Gets Its Feathers: Insights from Chromatin Looping

3 citations, June 2020 in “Developmental Cell”

Feather patterns are influenced by enhancers and chromatin looping, and the structure of protein complexes important for hair growth has been detailed.

research Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole

28 citations, September 2021 in “EMBO reports”

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

5 citations, September 2022 in “Molecular pharmacology”

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

6 citations, May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

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community Hair Growth Journey: 10 months

in Progress Pictures 252 upvotes 6 months ago

A 31-year-old who experienced severe hair loss during medical school tried various treatments, including topical and oral finasteride and minoxidil, but stopped due to side effects. They restarted treatment 10 months ago with a regimen including topical finasteride, minoxidil, retinoic acid, hydrocortisone, oral minoxidil, and light therapy, emphasizing the importance of consistency and skincare.

community Progression blindness? 4 months Spironoloctone 50mg twice a day

in Progress Pictures 102 upvotes 6 months ago

User shared progress on hair regrowth after 4 months of Spironolactone and iron infusions for Androgenic Alopecia. They see some improvement but struggle with perception; others note significant improvement.