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The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Feather patterns are influenced by enhancers and chromatin looping, and the structure of protein complexes important for hair growth has been detailed.

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

Dermal EZH2 controls skin cell development and hair growth in mice.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

COVID-19 may harm male fertility and damage the reproductive system.

The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.

Dermal EZH2 controls skin cell growth and differentiation in mice.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

External factors can cause skin cancer cells that usually don't spread to grow and form tumors in mice.

New therapies are being developed that target integrin pathways to treat various diseases.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

No single biomarker is reliable enough for diagnosing and assessing SLE.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

COVID-19 may affect male fertility and women might have better outcomes due to hormonal and immune differences.

Social media data can help track and predict COVID-19 symptoms and trends.

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

Gamma delta T cells in the skin help with healing and defense but can also cause autoimmune issues, and more research is needed to understand how they are activated.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

AtVPS29 is essential for proper plant growth by regulating gibberellin signaling.