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Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

research Adrenal Causes of Endocrine Hypertension in Childhood or Adolescence

June 2025 in “Journal of Endocrinological Investigation”

Adrenal disorders often cause high blood pressure in young people.

research Mechanisms of Proton Inhibition and Sensitization of the Cation Channel TRPV3

15 citations , December 2020 in “The Journal of General Physiology”

Acid can block TRPV3 from outside the cell but boost its function from inside.

research How Biodegradable Polymers Can Be Effective Drug Delivery Systems for Cannabinoids: Perspectives and Challenges

May 2024 in “International Journal of Nanomedicine”

Biodegradable polymers can improve cannabinoid delivery but need more clinical trials.

research The Endocannabinoid System of the Skin: A Potential Approach for the Treatment of Skin Disorders

75 citations , August 2018 in “Biochemical pharmacology”

Targeting the skin's endocannabinoid system could help treat skin disorders.

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Community Join

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community Is something finally happening here? What do you think?

in Is this regrowth? 11 upvotes 2 years ago

The conversation discusses hair regrowth using RU58841 and Minoxidil in the morning, and Minoxidil with needle massage in the evening. The user is inquiring if there are signs of hair regrowth by comparing photos from September 3 to recent ones.

community Switched from finasteride to dutasteride - 2 month update

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.

community Hair came back in 3 months at 39y/o.

in Progress Pictures 421 upvotes 2 years ago

A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

community Does discontinuing Minoxidil cause permanent damage to your hair?

in Minoxidil 16 upvotes 1 year ago

Discontinuing Minoxidil typically returns hair to baseline, but some believe it may go below baseline temporarily. Continuing finasteride or dutasteride is recommended.

community Is Trump no longer on finasteride?

in Finasteride/Dutasteride 258 upvotes 11 months ago

Trump's health report omits finasteride, sparking speculation about whether he stopped using it or switched treatments. Some believe he might not prioritize hair maintenance anymore.

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