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Glossary Pain

unpleasant sensation signaling potential or actual tissue damage

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. It serves as a warning signal to the body, prompting protective actions. For professionals, pain can be classified into various types, such as acute or chronic, and can be assessed using scales to determine its intensity and impact on a patient's quality of life.

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Research

5 / 1000+ results

research Somatosensory organization and behavior in naked mole‐rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain

101 citations , August 2003 in “Journal of comparative neurology”

In this study, naked mole-rats demonstrated unique skin and hair follicle innervation features compared to other species, suggesting adaptations to their subterranean environment and poikilothermy.

research Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

61 citations , September 2011 in “Pain”

This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

research Multiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing

37 citations , December 2024 in “Theranostics”

In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.

research Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes

35 citations , January 2022 in “Frontiers in Neurology”

This review utilizes clinical vignettes to detail various pain syndromes associated with multiple sclerosis, including their pathophysiology and management strategies, highlighting conditions like central neuropathic pain, Lhermitte's phenomenon, and trigeminal neuralgia as they relate to different lesion types.

research Safety and Efficacy of Intravenous ExoFlo in the Treatment of Complex Regional Pain Syndrome

9 citations , November 2023 in “Pain Physician”

This study suggests that IV delivery of ExoFlo may be a safe and effective treatment for addressing symptoms in CRPS patients, warranting further investigation.

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Community Join

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community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community Anyone notice pain in scalp alongside hairloss?

10 upvotes 1 month ago

Scalp pain alongside hair loss may indicate inflammation rather than just male pattern baldness. Treatments mentioned include triamcinolone acetonide, fluocinonide, Head & Shoulders shampoo, aloe vera gel, finasteride, and 2% Nizoral.

community Chest pain on Oral minoxidil (18M)

in Minoxidil 38 upvotes 7 months ago

An 18-year-old experienced chest pain, headaches, and vomiting after taking oral minoxidil for hair loss. They reduced the dosage, felt better, but experienced sharp chest pain again after increasing it, and are advised to stop the medication and see a doctor.

community Testicular pain/discomfort....how long will this last? (29/m)

5 upvotes 9 years ago

A user experienced testicular pain after taking finasteride for hair loss and considered lowering the dose to 0.25mg to manage side effects. They also considered adding minoxidil to their routine while seeking advice on whether to continue or stop finasteride.

community Severe Testicular Pain After 2 Weeks on Oral Finasteride – Is This Normal?

in General 30 upvotes 6 months ago

A user experienced severe testicular pain after two weeks on oral finasteride. Another user suggested that while rare, this side effect can occur and recommended considering topical finasteride if the pain persists.

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Learn

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learn Scalp Micropigmentation

Can I take painkillers before my scalp micropigmentation session? Most providers suggest paracetamol about an hour before an SMP session and caution against aspirin, while their advice on ibuprofen is split. Ask a doctor or pharmacist first, and never stop a prescribed blood thinner for a cosmetic appointment.
Will I experience pain after the scalp micropigmentation treatment? You may feel discomfort during the procedure and soreness afterward.

learn Hair Transplant

Is a hair transplant painful? Clinics say local anaesthetic makes the procedure itself mostly comfortable, but the anaesthetic injections sting and soreness for a few days afterwards is common. Pain varies from person to person.
Will I feel pain during a hair transplant? Clinics say local anesthetic keeps the procedure mostly comfortable; the injections sting, and soreness afterwards is common.
Is FUE painful? Local anesthetic injections sting, then the procedure is usually tolerable; soreness, swelling and donor-area pain are common for several days.

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Clinics

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Experts

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Hair System Specialist
Suparno Paine
Kolkata, West Bengal, India

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Suparno Paine