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    Glossary Skin Thickening

    process where skin becomes thicker due to chronic irritation

    Skin thickening, also known as lichenification, refers to the process where the skin becomes thicker and leathery due to chronic inflammation or repeated irritation. This condition often results from persistent scratching or rubbing, leading to an exaggerated skin cell production and a more pronounced skin texture. It is commonly seen in conditions like eczema or chronic dermatitis.

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    1. Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits BMC Genomics · 2024 · 2 citations
    2. Morphological analysis of patchy thickening and reddish discoloration of active hair growth areas in the skin of New Zealand White rabbits Journal of toxicologic pathology · 2017 · 6 citations
    3. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    4. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    5. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis 2008 · 148 citations
    6. Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism PLoS Medicine · 2006 · 135 citations
    7. RASopathic Skin Eruptions during Vemurafenib Therapy PLoS ONE · 2013 · 82 citations
    8. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice EMBO molecular medicine · 2014 · 81 citations
    9. Penetration and Local Effect of Vitamin A on the Skin of the Guinea Pig., Experimental Biology and Medicine · 1954 · 45 citations
    10. Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin Journal of Biological Chemistry · 2011 · 35 citations
    11. Cutaneous Ultrastructural Features of the Flaky Skin (<i>fsn</i>) Mouse Mutation The Journal of Dermatology · 1995 · 28 citations
    12. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene 2015 · 22 citations
    13. Epidermal dysplasia and <i>Malassezia</i> infection in two West Highland White Terrier siblings: an inherited skin disorder or reaction to severe <i>Malassezia</i> infection? Veterinary dermatology · 2001 · 17 citations
    14. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation 2015 · 16 citations
    15. miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades Journal of Advanced Research · 2024 · 15 citations
    16. Lesions in the skin, intestine, and central nervous system induced by an antimetabolite of niacin. PubMed · 1986 · 12 citations
    17. Antigen presenting cells in the skin of a patient with hair loss and systemic lupus erythematosus. PubMed · 2009 · 9 citations
    18. Dorsal skin responses to subchronic ultraviolet B (UVB)-irradiation in Wistar-derived hypotrichotic WBN/ILA-Ht rats. PubMed · 2002 · 7 citations
    19. Wound healing mechanism in Mongolian gerbil skin Histochemistry and Cell Biology · 2018 · 6 citations
    20. Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures Frontiers in cell and developmental biology · 2021 · 5 citations
    21. Tracing the Change and Contribution of Subcutaneous Adipose to Skin Expansion Using a Luciferase-Transgenic Fat Transplantation Model Plastic & Reconstructive Surgery · 2023 · 4 citations
    22. Correction: RASopathic Skin Eruptions during Vemurafenib Therapy PLoS ONE · 2013 · 4 citations
    23. Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis due to Sarcoptes scabiei Journal of comparative pathology · 2021 · 2 citations
    24. Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology American Journal of Clinical Dermatology · 2026
    25. The Effect of Microneedling on Skin Histology: Review of Literature 2024
    26. Skin alterations as possible clinical markers of diabetes mellitus and metabolic syndrome Russian Journal of Preventive Medicine · 2024
    27. SKIN MANIFESTATIONS OF RHEUMATOLOGICAL DISEASES Rheumatology quarterly · 2024
    28. Topical olive oil with downregulation of stress factors protects mice skin from precarious 3600 MHz electromagnetic radiation. The Egyptian Journal of Histology · 2020
    29. 915 Dietary grape powder inhibits atopic dermatitis-like skin lesions in NC/Nga mice Journal of Investigative Dermatology · 2019
    30. Congenital and Hereditary Skin Diseases 2018