Dietary Grape Powder Inhibits Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
April 2019
in “
Journal of Investigative Dermatology
”
atopic dermatitis dietary grape powder skin lesions acanthosis mast cell infiltration lymphatic expansion hematopoietic expansion serum IgE levels cytokines chemokines acute phase response pathway signaling molecules AD GP skin thickening immune cells immune system expansion allergy antibodies immune proteins inflammatory proteins immune response pathway cell signaling
TLDR Eating grape powder may reduce the severity of skin allergy symptoms.
The study from May 2019 examined the impact of dietary grape powder (GP) on atopic dermatitis (AD) in NC/Nga mice over a 13-week period, using concentrations of 3% or 5% GP in both prevention and intervention scenarios. The findings indicated that GP significantly reduced the development and progression of AD-like skin lesions, decreased skin acanthosis and mast cell infiltration, and reduced lymphatic/hematopoietic expansion in spleens and lymph nodes. GP also lowered serum IgE levels and modulated 14 serum cytokines/chemokines, suggesting an alleviation of AD symptoms. Proteomics and Ingenuity Pathway Analysis revealed that the 'acute phase response pathway' was notably affected by GP, implicating several AD-associated signaling molecules. The study concluded that GP could potentially reduce the severity of AD and recommended further research for validation.
