Correction: RASopathic Skin Eruptions During Vemurafenib Therapy

    October 2013 in “ PLoS ONE ”
    Jeannine D. Rinderknecht, Simone M. Goldinger, Sima Rozati, Jivko Kamarashev, Katrin Kerl, Lars E. French, Reinhard Dummer, Benedetta Belloni
    TLDR Vemurafenib causes significant skin side effects, requiring regular dermatologist care and sun protection.
    The study investigated the cutaneous side effects of Vemurafenib, a treatment for advanced melanoma, in 28 patients. It found that 93% of patients experienced skin reactions, including photosensitivity, maculopapular exanthema, pruritus, folliculitis, burning feet, mild alopecia, curly hair, and nail changes. Common skin reactions also included keratosis pilaris, acanthopapilloma, plantar hyperkeratosis, keratoacanthoma, and invasive squamous cell carcinoma. One patient developed a second primary melanoma. The study concluded that Vemurafenib's side effects resemble those of RASopathies and emphasized the need for regular skin examinations, management by dermatologists, and continuous photo protection.
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