Correction: RASopathic Skin Eruptions During Vemurafenib Therapy
October 2013
in “
PLoS ONE
”
Studysummary This study found that Vemurafenib led to a broad range of cutaneous side effects in nearly all patients with advanced melanoma, highlighting the need for regular dermatologic management and UV protection.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the cutaneous side effects of Vemurafenib, a treatment for advanced melanoma, in 28 patients. It found that 93% of patients experienced skin reactions, including photosensitivity, maculopapular exanthema, pruritus, folliculitis, burning feet, mild alopecia, curly hair, and nail changes. Common skin reactions also included keratosis pilaris, acanthopapilloma, plantar hyperkeratosis, keratoacanthoma, and invasive squamous cell carcinoma. One patient developed a second primary melanoma. The study concluded that Vemurafenib's side effects resemble those of RASopathies and emphasized the need for regular skin examinations, management by dermatologists, and continuous photo protection.
