TLDR Targeted anticancer therapies in children often cause skin side effects like rash and dry skin.
The document analyzed dermatologic adverse events (AEs) in pediatric patients receiving targeted anticancer therapies across 19 clinical trials involving 955 patients. Common AEs included rash (19%), xerosis (18%), mucositis (17%), and pruritus (7%), with hair disorders such as trichomegaly and alopecia also noted. The study emphasized the significant morbidity associated with these AEs and the need for pediatric oncologists to recognize and manage these conditions to avoid unnecessary dose modifications or therapy discontinuation, thereby maintaining patients' quality of life. The inclusion of dermatologists in the care team and personalized pre-therapy counseling were recommended to improve clinical outcomes.
42 citations
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April 2012 in “Seminars in Oncology” Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.
38 citations
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February 2012 in “Supportive Care in Cancer” Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.
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June 1997 in “PubMed” EGFR is essential for normal hair development and follicle differentiation.
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January 2012 in “International Journal of Dermatology” Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.
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September 2017 in “Oncology and therapy” The document provides advice on how to recognize and treat skin-related side effects of cancer drugs known as EGFR inhibitors.
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October 2018 in “Springer eBooks” Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.
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October 2011 in “Clinics in Dermatology” New chemotherapy drugs cause skin side effects, but treatments like minocycline and tetracycline can help reduce them.
1 citations
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January 2015 in “Springer eBooks” Chemotherapy can cause skin side effects that affect patients' lives, but they can be managed to avoid interrupting cancer treatment.
